The prevalence of paramagnetic rim lesions in multiple sclerosis: A systematic review and meta-analysis.

ABSTRACT:

Background

Recent findings from several studies have shown that paramagnetic rim lesions identified using susceptibility-based MRI could represent potential diagnostic and prognostic biomarkers in multiple sclerosis (MS). Here, we perform a systematic review and meta-analysis of the existing literature to assess their pooled prevalence at lesion-level and patient-level.

Methods

Both database searching (PubMed and Embase) and handsearching were conducted to identify studies allowing the lesion-level and/or patient-level prevalence of rim lesions or chronic active lesions to be calculated. Pooled prevalence was estimated using the DerSimonian-Laird random-effects model. Subgroup analysis and meta-regression were performed to explore possible sources of heterogeneity. PROSPERO

SUBMITTER: Ng Kee Kwong KC 

PROVIDER: S-EPMC8425533 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature