Prognostic Factors and Long-Term Outcome with ANCA-Associated Kidney Vasculitis in Childhood.

ABSTRACT:

Background and objectives

ANCA-associated vasculitis is extremely rare in children. We report the clinicopathologic features, long-term outcomes, and prognostic factors of a large pediatric cohort of patients with ANCA-associated kidney vasculitis.

Design, setting, participants, & measurements

This retrospective study included 85 consecutive patients with kidney biopsy specimen-proven ANCA-associated vasculitis from tertiary referral centers in Italy and Canada. Kidney biopsy specimens were categorized as focal, crescentic, sclerotic, or mixed, according to the Berden classification. The prognostic significance of baseline clinical, laboratory, and histologic findings was analyzed with respect to kidney failure or CKD stage 3-5/kidney failure.

Results

A total of 53 pa

SUBMITTER: Calatroni M 

PROVIDER: S-EPMC8425616 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature