Early Humoral Responses of Hemodialysis Patients after COVID-19 Vaccination with BNT162b2.

ABSTRACT:

Background and objectives

Patients receiving hemodialysis are at high risk for both severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and severe coronavirus disease 2019. A lifesaving vaccine is available, but sensitivity to vaccines is generally lower in patients on dialysis. Little is yet known about antibody responses after coronavirus disease 2019 (COVID-19) vaccination in this vulnerable group.

Design, setting, participants, and measurements

In this prospective single-center study, we included 22 patients on dialysis and 46 healthy controls from Heidelberg University Hospital between December 2020 and February 2021. We measured anti-S1 IgG with a threshold index for detection greater than one, neutralizing antibodies with a threshold for viral neutr

SUBMITTER: Speer C 

PROVIDER: S-EPMC8425619 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature