<i>In vivo</i> trafficking of a tumor-targeting IgE antibody: molecular imaging demonstrates rapid hepatobiliary clearance compared to IgG counterpart.

ABSTRACT: IgE antibodies elicit powerful immune responses, recruiting effector cells to tumors more efficiently and with greater cytotoxicity than IgG antibodies. Consequently, IgE antibodies are a promising alternative to conventional IgG-based therapies in oncology (AllergoOncology). As the pharmacokinetics of IgE antibodies are less well understood, we used molecular imaging in mice to compare the distribution and elimination of IgE and IgG antibodies targeting the human tumor-associated antigen chondroitin sulfate proteoglycan 4 (CSPG4). Anti-CSPG4 IgE and IgG1 antibodies with human Fc domains were radiolabeled with ¹¹¹In. CSPG4-expressing A375 human melanoma xenografts implanted in NOD-scid IL2rg^-/- mice were also engrafted with human immune cells by intravenous adm

SUBMITTER: Man F 

PROVIDER: S-EPMC8425638 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature