Platelet Function in CKD: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Patients with CKD are at high risk for thrombotic and hemorrhagic complications. Abnormalities in platelet function are central to these complications, but reports on platelet function in relation to CKD are conflicting, and vary from decreased platelet reactivity to normal or increased platelet responsiveness. The direct effects of uremic toxins on platelet function have been described, with variable findings.

Methods

To help clarify how CKD affects platelet function, we conducted a systematic review and meta-analysis of platelet activity in CKD, with a focus on nondialysis-induced effects. We also performed an extensive literature search for the effects of individual uremic toxins on platelet function.

Results

We included 73 studies in the systematic revi

SUBMITTER: Baaten CCFMJ 

PROVIDER: S-EPMC8425648 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature