Viral intra-host evolution in immunocompetent children contributes to human norovirus diversification at the global scale.

ABSTRACT: Norovirus is a major cause of acute gastroenteritis. Human noroviruses present >30 different genotypes, with a single genotype (GII.4) predominating worldwide. Concurrent outbreaks of norovirus are often associated with the emergence of new viruses. While different hypotheses have been presented, the source of new mutations in noroviruses is still unknown. In this study, we applied high-resolution sequencing to determine the intra-host viral diversity presented by noroviruses during the acute and shedding phase of infection in children. Profiling viral intra-host diversification at nearly full genome level indicated that GII.4 viruses presented dynamic intra-host variation, while non-GII.4 viruses presented minimal variation throughout the infection. Notably, the intra-host genetic variati

SUBMITTER: Tohma K 

PROVIDER: S-EPMC8425682 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature