Network pharmacology-based analysis in determining the mechanisms of Huoxin pill in protecting against myocardial infarction.

ABSTRACT:

Context

Huoxin pill (HXP) is a commonly used TCM prescription for treatment of cardiovascular diseases. However, its mechanism in protecting against myocardial infarction (MI) remains unknown.

Objective

We performed a network pharmacology analysis to explore the bioactive ingredients, therapeutic effects, and mechanisms of HXP in protecting against MI.

Materials and methods

HPLC was used to identify major bioactive compounds, and overlap with MI target genes were visualised. 10-Week old C57BL/6 mice were randomly assigned as: Sham-operated control, MI + Phosphate buffered saline (PBS), and MI + HXP (3 mg/mL and 9 mg/mL) treatment groups, received oral gavage administration once every two-days starting from 1-week prior to MI, and subsequently MI models were establishe

SUBMITTER: He J 

PROVIDER: S-EPMC8425702 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature