Immunologic resilience and COVID-19 survival advantage.

ABSTRACT:

Background

The risk of severe coronavirus disease 2019 (COVID-19) varies significantly among persons of similar age and is higher in males. Age-independent, sex-biased differences in susceptibility to severe COVID-19 may be ascribable to deficits in a sexually dimorphic protective attribute that we termed immunologic resilience (IR).

Objective

We sought to examine whether deficits in IR that antedate or are induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection independently predict COVID-19 mortality.

Methods

IR levels were quantified with 2 novel metrics: immune health grades (IHG-I [best] to IHG-IV) to gauge CD8⁺ and CD4⁺ T-cell count equilibrium, and blood gene expression signatures. IR metrics were examined in a pr

SUBMITTER: Lee GC 

PROVIDER: S-EPMC8425719 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature