Biomarkers for Adverse Lung Injury Following Pediatric Cardiopulmonary Bypass.

ABSTRACT: Cardiopulmonary bypass triggers systemic inflammation, resulting in lung injury, and frequently leads to prolonged mechanical ventilation. Biomarkers of systemic inflammation are required to predict the risk of such complications. We hypothesize that specific serum proteins can be used as biomarkers to predict the severity of lung injury following cardiac surgery.

Design

Retrospective chart review study.

Setting

Clinical variables were collected and used in conjuncture with unbiased proteomic analysis using mass spectrometry that was performed on frozen plasma samples from a study group (patients with mechanical ventilation > 48 hr post surgery) and a control group (patients with mechanical ventilation < 48 hr post surgery).

Subjects

Subjects included were infants who

SUBMITTER: Asfari A 

PROVIDER: S-EPMC8425845 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature