Versatile Ice Microneedles for Transdermal Delivery of Diverse Actives.

ABSTRACT: Microneedles are regarded as an emerging and promising transdermal drug delivery strategy. Great efforts are devoted to getting rid of their material restrictions and imparting them with abilities to carry various drugs. Here, inspired by ice formation in nature and based on characteristics of different frozen materials, the authors present novel ice microneedles made from versatile soft materials using a simple freezing template-based fabrication stratagem for effective transdermal delivery of diverse actives. Their strategy can convert microneedles with almost all water-containing components from softness into hardness for guaranteeing satisfactory penetration, thus removing their material component limitations. As all fabrication procedures are mild and actives can maintain activity dur

SUBMITTER: Zhang X 

PROVIDER: S-EPMC8425882 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature