Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave.

ABSTRACT: Microglia, the brain's resident myeloid cells, play central roles in brain defense, homeostasis, and disease. Using a prolonged colony-stimulating factor 1 receptor inhibitor (CSF1Ri) approach, we report an unprecedented level of microglial depletion and establish a model system that achieves an empty microglial niche in the adult brain. We identify a myeloid cell that migrates from the subventricular zone and associated white matter areas. Following CSF1Ri, these amoeboid cells migrate radially and tangentially in a dynamic wave filling the brain in a distinct pattern, to replace the microglial-depleted brain. These repopulating cells are enriched in disease-associated microglia genes and exhibit similar phenotypic and transcriptional profiles to white-matter-associated microglia. Our fin

SUBMITTER: Hohsfield LA 

PROVIDER: S-EPMC8425950 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature