A Framework for Systematic Assessment of Clinical Trial Population Representativeness Using Electronic Health Records Data.

ABSTRACT:

Background

Clinical trials are the gold standard for generating robust medical evidence, but clinical trial results often raise generalizability concerns, which can be attributed to the lack of population representativeness. The electronic health records (EHRs) data are useful for estimating the population representativeness of clinical trial study population.

Objectives

This research aims to estimate the population representativeness of clinical trials systematically using EHR data during the early design stage.

Methods

We present an end-to-end analytical framework for transforming free-text clinical trial eligibility criteria into executable database queries conformant with the Observational Medical Outcomes Partnership Common Data Model and for systematically quant

SUBMITTER: Sun Y 

PROVIDER: S-EPMC8426045 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature