Fronto-thalamic structural and effective connectivity and delusions in schizophrenia: a combined DTI/DCM study.

ABSTRACT:

Background

Schizophrenia (SZ) is a complex disorder characterized by a range of behavioral and cognitive symptoms as well as structural and functional alterations in multiple cortical and subcortical structures. SZ is associated with reduced functional network connectivity involving core regions such as the anterior cingulate cortex (ACC) and the thalamus. However, little is known whether effective coupling, the directed influence of one structure over the other, is altered during rest in the ACC-thalamus network.

Methods

We collected resting-state fMRI and diffusion-weighted MRI data from 18 patients and 20 healthy controls. We analyzed fronto-thalamic effective connectivity using dynamic causal modeling for cross-spectral densities in a network consisting of the ACC and th

SUBMITTER: Csukly G 

PROVIDER: S-EPMC8426148 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature