Rapid and stable mobilization of CD8⁺ T cells by SARS-CoV-2 mRNA vaccine.

ABSTRACT: SARS-CoV-2 spike mRNA vaccines^1-3 mediate protection from severe disease as early as ten days after prime vaccination³, when neutralizing antibodies are hardly detectable^4-6. Vaccine-induced CD8⁺ T cells may therefore be the main mediators of protection at this early stage^7,8. The details of their induction, comparison to natural infection, and association with other arms of vaccine-induced immunity remain, however, incompletely understood. Here we show on a single-epitope level that a stable and fully functional CD8⁺ T cell response is vigorously mobilized one week after prime vaccination with bnt162b2, when circulating CD4⁺ T cells and neutralizing antibodies are still weakly detectable. Boost vaccination induce

SUBMITTER: Oberhardt V 

PROVIDER: S-EPMC8426185 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature