Pulmonary infection induces persistent, pathogen-specific lipidomic changes influencing trained immunity.

ABSTRACT: Resolution of infection results in development of trained innate immunity which is typically beneficial for defense against unrelated secondary infection. Epigenetic changes including modification of histones via binding of various polar metabolites underlie the establishment of trained innate immunity. Therefore, host metabolism and this response are intimately linked. However, little is known regarding the influence of lipids on the development and function of trained immunity. Utilizing two models of pulmonary bacterial infection combined with multi-omic approaches, we identified persistent, pathogen-specific changes to the lung lipidome that correlated with differences in the trained immune response against a third unrelated pathogen. Further, we establish the specific cellular populat

SUBMITTER: Roberts LM 

PROVIDER: S-EPMC8426275 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature