Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking.

ABSTRACT: Increased risk-taking is a central component of bipolar disorder (BIP) and is implicated in schizophrenia (SCZ). Risky behaviours, including smoking and alcohol use, are overrepresented in both disorders and associated with poor health outcomes. Positive genetic correlations are reported but an improved understanding of the shared genetic architecture between risk phenotypes and psychiatric disorders may provide insights into underlying neurobiological mechanisms. We aimed to characterise the genetic overlap between risk phenotypes and SCZ, and BIP by estimating the total number of shared variants using the bivariate causal mixture model and identifying shared genomic loci using the conjunctional false discovery rate method. Summary statistics from genome wide association studies of SCZ, B

SUBMITTER: Hindley G 

PROVIDER: S-EPMC8426401 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature