Activation Phenotype of Mycobacterium tuberculosis-Specific CD4⁺ T Cells Promoting the Discrimination Between Active Tuberculosis and Latent Tuberculosis Infection.

ABSTRACT:

Background

Rapid and effective discrimination between active tuberculosis (ATB) and latent tuberculosis infection (LTBI) remains a challenge. There is an urgent need for developing practical and affordable approaches targeting this issue.

Methods

Participants with ATB and LTBI were recruited at Tongji Hospital (Qiaokou cohort) and Sino-French New City Hospital (Caidian cohort) based on positive T-SPOT results from June 2020 to January 2021. The expression of activation markers including HLA-DR, CD38, CD69, and CD25 was examined on Mycobacterium tuberculosis (MTB)-specific CD4⁺ T cells defined by IFN-γ, TNF-α, and IL-2 expression upon MTB antigen stimulation.

Results

A total of 90 (40 ATB and 50 LTBI) and another 64 (29 ATB and 35 LTBI) subjects were

SUBMITTER: Luo Y 

PROVIDER: S-EPMC8426432 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature