Strain and sex dependent effects of isolation housing relative to environmental enrichment on operant sensation seeking in mice.

ABSTRACT: Sensation seeking is a multidimensional phenotype that predicts the development of drug addiction in humans and addiction-like drug seeking in rodents. Several lines of evidence suggest that chronic stress increases sensation seeking and addiction-like drug seeking through common genetic mechanisms. Discovery and characterization of these mechanisms would reveal how chronic stress interacts with the genome to influence sensation seeking and how drugs of abuse hijack these fundamental reward mechanisms to drive addiction. To this end, we tested the hypothesis that chronic isolation housing stress (relative to environmental enrichment) influences operant sensation seeking as a function of strain, sex, or their interaction. To determine if the BXD recombinant inbred panel could be used to ide

SUBMITTER: Dickson PE 

PROVIDER: S-EPMC8426458 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature