Altered Neurocognitive Functional Connectivity and Activation Patterns Underlie Psychopathology in Preadolescence.

ABSTRACT:

Background

Neurocognitive deficits are common among youth with mental disorders, and patterns of aberrant brain function generally cross diagnostic boundaries. This study investigated associations between functional neurocircuitry and broad transdiagnostic psychopathology dimensions in the critical preadolescent period when psychopathology is emerging.

Methods

Participants were 9- to 10-year-olds from the Adolescent Brain Cognitive Development Study. Factor scores of general psychopathology, externalizing, internalizing, and thought disorder dimensions were calculated from a higher-order model of psychopathology using confirmatory factor analysis (N = 11,721) and entered as explanatory variables into linear mixed models to examine associations with resting-state functional c

SUBMITTER: Lees B 

PROVIDER: S-EPMC8426459 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature