CISD3 inhibition drives cystine-deprivation induced ferroptosis.

ABSTRACT: Ferroptosis, a new form of programmed cell death, not only promotes the pathological process of various human diseases, but also regulates cancer progression. Current perspectives on the underlying mechanisms remain largely unknown. Herein, we report a member of the NEET protein family, CISD3, exerts a regulatory role in cancer progression and ferroptosis both in vivo and in vitro. Pan-cancer analysis from TCGA reveals that expression of CISD3 is generally elevated in various human cancers which are consequently associated with a higher hazard ratio and poorer overall survival. Moreover, knockdown of CISD3 significantly accelerates lipid peroxidation and accentuates free iron accumulation triggered by Xc^- inhibition or cystine-deprivation, thus causing ferroptotic cell death. Co

SUBMITTER: Li Y 

PROVIDER: S-EPMC8426496 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature