MULocDeep: A deep-learning framework for protein subcellular and suborganellar localization prediction with residue-level interpretation.

ABSTRACT: Prediction of protein localization plays an important role in understanding protein function and mechanisms. In this paper, we propose a general deep learning-based localization prediction framework, MULocDeep, which can predict multiple localizations of a protein at both subcellular and suborganellar levels. We collected a dataset with 44 suborganellar localization annotations in 10 major subcellular compartments-the most comprehensive suborganelle localization dataset to date. We also experimentally generated an independent dataset of mitochondrial proteins in Arabidopsis thaliana cell cultures, Solanum tuberosum tubers, and Vicia faba roots and made this dataset publicly available. Evaluations using the above datasets show that overall, MULocDeep outperforms other m

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC8426535 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature