A host lipase prevents lipopolysaccharide-induced foam cell formation.

ABSTRACT: Although microbe-associated molecular pattern (MAMP) molecules can promote cholesterol accumulation in macrophages, the existence of a host-derived MAMP inactivation mechanism that prevents foam cell formation has not been described. Here, we tested the ability of acyloxyacyl hydrolase (AOAH), the host lipase that inactivates gram-negative bacterial lipopolysaccharides (LPSs), to prevent foam cell formation in mice. Following exposure to small intraperitoneal dose(s) of LPSs, Aoah ^-/- macrophages produced more low-density lipoprotein receptor and less apolipoprotein E and accumulated more cholesterol than did Aoah ^+/+ macrophages. The Aoah ^-/- macrophages also maintained several pro-inflammatory features. Using a pe

SUBMITTER: Feng J 

PROVIDER: S-EPMC8426562 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature