ABSTRACT: The second wave of COVID-19 has caused a dramatic increase in COVID-19 cases and deaths globally. An accurate prediction of its development trend is significant. We predicted the development trend of the second wave of COVID-19 in five European countries, including France, Germany, Italy, Spain, and the UK. We first built models to predict daily numbers of COVID-19 cases and deaths based on the data of the first wave of COVID-19 in these countries. Based on these models, we built new models to predict the development trend of the second wave of COVID-19. We predicted that the second wave of COVID-19 would have peaked around on November 16, 2020, January 10, 2021, December 1, 2020, March 1, 2021, and January 10, 2021, in France, Germany, Italy, Spain, and the UK, respectively. It will be ba