Evolution of viral variants in remdesivir-treated and untreated SARS-CoV-2-infected pediatrics patients.

ABSTRACT: Detailed information on intrahost viral evolution in SARS-CoV-2 with and without treatment is limited. Sequential viral loads and deep sequencing of SARS-CoV-2 from the upper respiratory tract of nine hospitalized children, three of whom were treated with remdesivir, revealed that remdesivir treatment suppressed viral load in one patient but not in a second infected with an identical strain without any evidence of drug resistance found. Reduced levels of subgenomic RNA during treatment of the second patient, suggest an additional effect of remdesivir on viral replication. Haplotype reconstruction uncovered persistent SARS-CoV-2 variant genotypes in four patients. These likely arose from within-host evolution, although superinfection cannot be excluded in one case. Although our dataset is s

SUBMITTER: Boshier FAT 

PROVIDER: S-EPMC8426849 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature