Influence of eye movement on lens dose and optic nerve target coverage during craniospinal irradiation.

ABSTRACT:

Purpose

Optic nerves are part of the craniospinal irradiation (CSI) target volume. Modern radiotherapy techniques achieve highly conformal target doses while avoiding organs-at-risk such as the lens. The magnitude of eye movement and its influence on CSI target- and avoidance volumes are unclear. We aimed to evaluate the movement-range of lenses and optic nerves and its influence on dose distribution of several planning techniques.

Methods

Ten volunteers underwent MRI scans in various gaze directions (neutral, left, right, cranial, caudal). Lenses, orbital optic nerves, optic discs and CSI target volumes were delineated. 36-Gy cranial irradiation plans were constructed on synthetic CT images in neutral gaze, with Volumetric Modulated Arc Therapy, pencil-beam scanning proton

SUBMITTER: Hoeben BAW 

PROVIDER: S-EPMC8427085 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature