Robust Antibody Responses to the BNT162b2 mRNA Vaccine Occur Within a Week After the First Dose in Previously Infected Individuals and After the Second Dose in Uninfected Individuals.

ABSTRACT:

Background

Vaccines against severe acute respiratory syndrome coronavirus 2 can trigger acquired immunity in infection-naïve individuals and offer a path toward ending the coronavirus disease pandemic that began in 2019. However, the kinetics of early antibody responses in vaccinated individuals remain poorly understood.

Method

We followed BNT162b2 mRNA-vaccinated health care workers (HCWs, N=108) including 103 infection-naïve and five previously infected individuals. A total of 763 blood samples were collected weekly or hourly basis before and after vaccination. Serological analysis of anti-spike and anti-nucleocapsid antibodies was performed.

Results

Seroconversion occurred in all infection-naïve HCWs 3 weeks after the first dose (just before the second vaccination)

SUBMITTER: Hirotsu Y 

PROVIDER: S-EPMC8427169 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature