Membrane Barrels Are Taller, Fatter, Inside-Out Soluble Barrels.

ABSTRACT: Up-and-down β-barrel topology exists in both the membrane and soluble environment. By comparing features of these structurally similar proteins, we can determine what features are particular to the environment rather than the fold. Here we compare structures of membrane β-barrels to soluble β-barrels and evaluate their relative size, shape, amino acid composition, hydrophobicity, and periodicity. We find that membrane β-barrels are generally larger than soluble β-barrels, with more strands per barrel and more amino acids per strand, making them wider and taller. We also find that membrane β-barrels are inside-out soluble β-barrels. The inward region of membrane β-barrels has similar hydrophobicity to the outward region of soluble β-barrels, and the outward region of membrane β-barrels has

SUBMITTER: Dhar R 

PROVIDER: S-EPMC8427218 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature