Mass Spectrometry-Based Targeted Serum Monomethylated Ribonucleosides Profiling for Early Detection of Breast Cancer.

ABSTRACT: RNA methylation plays a significant regulatory role in various of physiological activities and it has gradually become a hotspot of epigenetics in the past decade. 2'-O-methyladenosine (Am), 2'-O-methylguanosine (Gm), 2'-O-methylcytidine (Cm), 2'-O-methyluridine (Um), N ⁶-methyladenosine (m⁶A), N ¹-methylguanosine (m¹G), 5-methylcytidine (m⁵C), and 5-methyluridine (m⁵U) are representative 2'-O-methylation and base-methylation modified epigenetic marks of RNA. Abnormal levels of these ribonucleosides were found to be related to various diseases including cancer. Serum is an important source of biofluid for the discovery of biomarkers, and novel tumor biomarkers can be explored by measuring these ribonucleoside m

SUBMITTER: Fang Z 

PROVIDER: S-EPMC8427278 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature