Use of antipsychotic drugs and cholinesterase inhibitors and risk of falls and fractures: self-controlled case series.

ABSTRACT:

Objective

To evaluate the association between the use of antipsychotic drugs and cholinesterase inhibitors and the risk of falls and fractures in elderly patients with major neurocognitive disorders.

Design

Self-controlled case series.

Setting

Taiwan's National Health Insurance Database.

Participants

15 278 adults, aged ≥65, with newly prescribed antipsychotic drugs and cholinesterase inhibitors, who had an incident fall or fracture between 2006 and 2017. Prescription records of cholinesterase inhibitors confirmed the diagnosis of major neurocognitive disorders; all use of cholinesterase inhibitors was reviewed by experts.

Main outcome measures

Conditional Poisson regression was used to derive incidence rate ratios and 95% confidence intervals for evalua

SUBMITTER: Wang GH 

PROVIDER: S-EPMC8427404 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature