Wound healing activity of the hydroethanolic extract of the leaves of Maytenus ilicifolia Mart. Ex Reis.

ABSTRACT:

Background and aim

Maytenus ilicifolia has analgesic, healing, antioxidant and anti-inflammatory properties. This study evaluated effect of the hydroalcoholic extract of M. ilicifolia leaves on skin wound repair.

Experimental procedure

Wounds were induced on mice and treated with the extract. The treatment was performed daily, until day 7 after wound induction. Wound closure was measured and the features of the repaired tissue were investigated, including mast cell quantification, neutrophil and macrophage activities, collagen deposition, angiogenesis, and pro-metalloproteases and metalloproteases 2 and 9 activity (pro-MMPs and MMPs).

Results and conclusion

The M. ilicifolia extract accelerated the closure of wounds. The extract at a concentration

SUBMITTER: de Moura FBR 

PROVIDER: S-EPMC8427480 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature