Early-Onset Atrial Fibrillation and the Prevalence of Rare Variants in Cardiomyopathy and Arrhythmia Genes.

ABSTRACT:

Importance

Early-onset atrial fibrillation (AF) can be the initial manifestation of a more serious underlying inherited cardiomyopathy or arrhythmia syndrome.

Objective

To examine the results of genetic testing for early-onset AF.

Design, setting, and participants

This prospective, observational cohort study enrolled participants from an academic medical center who had AF diagnosed before 66 years of age and underwent whole genome sequencing through the National Heart, Lung, and Blood Institute's Trans-Omics for Precision Medicine program. Participants were enrolled from November 23, 1999, to June 2, 2015. Data analysis was performed from October 24, 2020, to March 11, 2021.

Exposures

Rare variants identified in a panel of 145 genes that are included on cardiom

SUBMITTER: Yoneda ZT 

PROVIDER: S-EPMC8427496 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature