Novel Therapies for Parkinsonian Syndromes-Recent Progress and Future Perspectives.

ABSTRACT: Background: Atypical parkinsonian syndromes are rare, fatal neurodegenerative diseases associated with abnormal protein accumulation in the brain. Examples of these syndromes include progressive supranuclear palsy, multiple system atrophy, and corticobasal degeneration. A common clinical feature in parkinsonism is a limited improvement with levodopa. So far, there are no disease-modifying treatments to address these conditions, and therapy is only limited to the alleviation of symptoms. Diagnosis is devastating for patients, as prognosis is extremely poor, and the disease tends to progress rapidly. Currently, potential causes and neuropathological mechanisms involved in these diseases are being widely investigated. Objectives: The goal of this review is to summarize recent ad

SUBMITTER: Przewodowska D 

PROVIDER: S-EPMC8427499 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature