A Prognostic Signature Constructed by CTHRC1 and LRFN4 in Stomach Adenocarcinoma.

ABSTRACT:

Background

Stomach adenocarcinoma (STAD) is the most common histological type of stomach cancer, which causes a considerable number of deaths worldwide. This study aimed to identify its potential biomarkers with the notion of revealing the underlying molecular mechanisms.

Methods

Gene expression profile microarray data were downloaded from the Gene Expression Omnibus (GEO) database. The "limma" R package was used to screen the differentially expressed genes (DEGs) between STAD and matched normal tissues. The Database for Annotation, Visualization, and Integrated Discovery (DAVID) was used for function enrichment analyses of DEGs. The STAD dataset from The Cancer Genome Atlas (TCGA) database was used to identify a prognostic gene signature, which was verified in another STAD

SUBMITTER: Han S 

PROVIDER: S-EPMC8427509 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature