Cerebral Microdialysate Metabolite Monitoring using Mid-infrared Spectroscopy.

ABSTRACT: The brains of patients suffering from traumatic brain-injury (TBI) undergo dynamic chemical changes in the days following the initial trauma. Accurate and timely monitoring of these changes is of paramount importance for improved patient outcome. Conventional brain-chemistry monitoring is performed off-line by collecting and manually transferring microdialysis samples to an enzymatic colorimetric bedside analyzer every hour, which detects and quantifies the molecules of interest. However, off-line, hourly monitoring means that any subhourly neurochemical changes, which may be detrimental to patients, go unseen and thus untreated. Mid-infrared (mid-IR) spectroscopy allows rapid, reagent-free, molecular fingerprinting of liquid samples, and can be easily integrated with microfluidics. We use

SUBMITTER: Alimagham FC 

PROVIDER: S-EPMC8427560 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature