Extensive alternative splicing triggered by mitonuclear mismatch in naturally introgressed Rhinolophus bats.

ABSTRACT: Mitochondrial function needs strong interactions of mitochondrial and nuclear (mitonuclear) genomes, which can be disrupted by mitonuclear mismatch due to mitochondrial DNA (mtDNA) introgression between two formerly isolated populations or taxa. This mitonuclear disruption may cause severe cellular stress in mismatched individuals. Gene expression changes and alternative splicing (AS) are two important transcriptional regulations to respond to environmental or cellular stresses. We previously identified a naturally introgressed population in the intermediate horseshoe bat (Rhinolophus affinis). Individuals from this population belong to R. a. himalayanus and share almost identical nuclear genetic background; however, some of them had mtDNA from another subspecies (R

SUBMITTER: Chen W 

PROVIDER: S-EPMC8427577 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature