Substituted Benzimidazole Analogues as Potential α-Amylase Inhibitors and Radical Scavengers.

ABSTRACT: Benzimidazole scaffolds are known to have a diverse range of biological activities and found to be antidiabetic and antioxidant. In this study, a variety of arylated benzimidazoles 1-31 were synthesized. Except for compounds 1, 6, 7, and 8, all are new derivatives. All compounds were screened for α-amylase inhibitory, 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activities. In vitro screening results revealed that all molecules demonstrated significant α-amylase inhibition with IC₅₀ values of 1.86 ± 0.08 to 3.16 ± 0.31 μM as compared to standard acarbose (IC₅₀ = 1.46 ± 0.26 μM). However, compounds showed significant ABTS and DPPH radical scavengi

SUBMITTER: Akande AA 

PROVIDER: S-EPMC8427641 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature