Brd4 Regulates the Homeostasis of CD8⁺ T-Lymphocytes and Their Proliferation in Response to Antigen Stimulation.

ABSTRACT: CD8⁺ T cells are major components of adaptive immunity and confer robust protective cellular immunity, which requires adequate T-cell numbers, targeted migration, and efficient T-cell proliferation. Altered CD8⁺ T-cell homeostasis and impaired proliferation result in dysfunctional immune response to infection or tumorigenesis. However, intrinsic factors controlling CD8⁺ T-cell homeostasis and immunity remain largely elusive. Here, we demonstrate the prominent role of Brd4 on CD8⁺ T cell homeostasis and immune response. By upregulating Myc and GLUT1 expression, Brd4 facilitates glucose uptake and energy production in mitochondria, subsequently supporting naïve CD8⁺ T-cell survival. Besides, Brd4 promotes the trafficking of naïve CD8

SUBMITTER: Peng Z 

PROVIDER: S-EPMC8427756 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature