Exploration of the Potential Mechanism of Tao Hong Si Wu Decoction for the Treatment of Breast Cancer Based on Network Pharmacology and In Vitro Experimental Verification.

ABSTRACT:

Background

Tao Hong Si Wu Decoction (THSWD) is a well-known traditional Chinese medicine used clinically alone or combined with drugs to treat breast cancer. However, there has been no study to date on the underlying mechanisms of its therapeutic effects.

Objectives

To explore the potential mechanism of THSWD for the treatment of breast cancer using network pharmacology and experimental research.

Methods

The active ingredients of THSWD were screened according to Lipinski's rule of five based on the 107 ingredients of THSWD identified by UPLC-Q-TOF-MS^E. The targets of THSWD and breast cancer from multiple databases were collected, and a Compound-Target-Pathway network based on protein-protein interaction (PPI) was constructed. Gene ontology (GO) analysis and

SUBMITTER: Huang S 

PROVIDER: S-EPMC8427760 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature