α-Glucosidase and PTP-1B Inhibitors from Malbranchea dendritica.

ABSTRACT: An extract from a PDB static culture of Malbranchea dendritica exhibited α-glucosidase and PTP-1B inhibitory activities. Fractionation of the active extract led to the isolation of gymnoascolide A (1), a γ-butenolide, and xanthones sydowinin A (2), sydowinin B (3), and AGI-B4 (4), as well as orcinol (5). Compound 1 exhibited important inhibitory activity against yeast α-glucosidase (IC₅₀ = 0.556 ± 0.009 mM) in comparison to acarbose (IC₅₀ = 0.403 ± 0.010 mM). Kinetic analysis revealed that 1 is a mixed-type inhibitor. Furthermore, compound 1 significantly reduced the postprandial peak in mice during a sucrose tolerance test at the doses of 5.16 and 10 mg/kg. Compound 1 was reduced with Pd/C to yield

SUBMITTER: Rebollar-Ramos D 

PROVIDER: S-EPMC8427789 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature