Reference values for IGF-I serum concentration in an adult population: use of the VARIETE cohort for two new immunoassays.

ABSTRACT:

Objective

Measurement of IGF-I is important in the management of patients with growth hormone disorders. Here we aim to establish normative data for two new IGF-I assay kits based on a large random sample of the French general adult population.

Subjects and methods

We measured IGF-I in 911 healthy adults (18-90 years) with two immunoassays (ROCHE Elecsys® and IMMULITE-2000 calibrated against the new IS 02/2547). We compared the data with those of the six immunoassays (iSYS, LIAISON XL, IMMULITE-2000 calibrated against the first IS 87/518, IGF-I RIACT, Mediagnost ELISA, and Mediagnost RIA) that we reported previously. The pairwise concordance among the eight assays was assessed with Bland-Altman plots for both the IGF-1 raw data and the standard deviation scores (SDS), as wel

SUBMITTER: Sabbah N 

PROVIDER: S-EPMC8428081 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature