Risk assessment of sepsis through measurement of proAVP (copeptin): a secondary analysis of the TRIAGE study.

ABSTRACT:

Objective

Systemic infections and sepsis lead to strong activation of the vasopressin system, which is pivotal for stimulation of the endocrine stress response and, in addition, has vasoconstrictive and immunomodulatory effects. Our aim was to assess the significance of the vasopressor system through measurement of C-terminal proAVP (copeptin) regarding mortality prediction in a large prospective cohort of patients with systemic infection.

Design and methods

This secondary analysis of the observational cohort TRIAGE study included consecutive, adult, medical patients with an initial diagnosis of infection seeking emergency department care. We used multivariable regression analysis to assess associations of copeptin levels in addition to the Sequential Organ Failure Assessmen

SUBMITTER: Kloter M 

PROVIDER: S-EPMC8428088 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature