Y chromosomal noncoding RNAs regulate autosomal gene expression via piRNAs in mouse testis.

ABSTRACT:

Background

Deciphering the functions of Y chromosome in mammals has been slow owing to the presence of repeats. Some of these repeats transcribe coding RNAs, the roles of which have been studied. Functions of the noncoding transcripts from Y chromosomal repeats however, remain unclear. While a majority of the genes expressed during spermatogenesis are autosomal, mice with different deletions of the long arm of the Y chromosome (Yq) were previously also shown to be characterized by subfertility, sterility and sperm abnormalities, suggesting the presence of effectors of spermatogenesis at this location. Here we report a set of novel noncoding RNAs from mouse Yq and explore their connection to some of the autosomal genes expressed in testis.

Results

We describe a set of novel m

SUBMITTER: Reddy HM 

PROVIDER: S-EPMC8428117 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature