MicroRNA-193-3p attenuates myocardial injury of mice with sepsis via STAT3/HMGB1 axis.

ABSTRACT:

Objective

Little is known regarding the functional role of microRNA-193-3p (miR-193-3p) in sepsis. Hence, the aim of the present study was to investigate the effect of miR-193-3p on myocardial injury in mice with sepsis and its mechanism through the regulation of signal transducers and activators of transcription 3 (STAT3).

Methods

The mice model of sepsis was established by cecal ligation and puncture (CLP), septic mice were injected with miR-193-3p agomir, miR-193-3p antagomir or siRNA-STAT3. The expression of miR-193-3p, STAT3 and HMGB1 in the myocardial tissue of septic mice were detected. Cardiac ultrasound, hemodynamics, myocardial injury markers, inflammatory factors and cardiomyocyte apoptosis in septic mice were measured.

Results

MiR-193-3p expression was red

SUBMITTER: Pan J 

PROVIDER: S-EPMC8428118 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature