Estimates of brain age for gray matter and white matter in younger and older adults: Insights into human intelligence.

ABSTRACT: Aging entails a multifaceted complex of changes in macro- and micro-structural properties of human brain gray matter (GM) and white matter (WM) tissues, as well as in intellectual abilities. To better capture tissue-specific brain aging, we combined volume and distribution properties of diffusivity indices to derive subject-specific age scores for each tissue. We compared age-related variance between younger and older adults for GM and WM age scores, and tested whether tissue-specific age scores could explain different effects of aging on fluid (Gf) and crystalized (Gc) intelligence in younger and older adults. Chronological age was strongly associated with GM (R² = 0.73) and WM (R² = 0.57) age scores. The GM age score accounted for significantly more variance in chro

SUBMITTER: Shokri-Kojori E 

PROVIDER: S-EPMC8428193 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature