FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue.

ABSTRACT: Preadipocytes dynamically produce sensory cilia. However, the role of primary cilia in preadipocyte differentiation and adipose homeostasis remains poorly understood. We previously identified transition fiber component FBF1 as an essential player in controlling selective cilia import. Here, we establish Fbf1^tm1a/tm1a mice and discover that Fbf1^tm1a/tm1a mice develop severe obesity, but surprisingly, are not predisposed to adverse metabolic complications. Obese Fbf1^tm1a/tm1a mice possess unexpectedly healthy white fat tissue characterized by spontaneous upregulated beiging, hyperplasia but not hypertrophy, and low inflammation along the lifetime. Mechanistically, FBF1 governs preadipocyte differentiation by constraining the beiging program through an AKAP9-d

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8428195 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature