SCISSOR™: a single-cell inferred site-specific omics resource for tumor microenvironment association study.

ABSTRACT: Tumor tissues are heterogeneous with different cell types in tumor microenvironment, which play an important role in tumorigenesis and tumor progression. Several computational algorithms and tools have been developed to infer the cell composition from bulk transcriptome profiles. However, they ignore the tissue specificity and thus a new resource for tissue-specific cell transcriptomic reference is needed for inferring cell composition in tumor microenvironment and exploring their association with clinical outcomes and tumor omics. In this study, we developed SCISSOR™ (https://thecailab.com/scissor/), an online open resource to fulfill that demand by integrating five orthogonal omics data of >6031 large-scale bulk samples, patient clinical outcomes and 451 917 high-granularity tissue-speci

SUBMITTER: Cui X 

PROVIDER: S-EPMC8428296 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature