SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway.

ABSTRACT: SARS-CoV-2 can infect multiple organs, including lung, intestine, kidney, heart, liver, and brain. The molecular details of how the virus navigates through diverse cellular environments and establishes replication are poorly defined. Here, we generated a panel of phenotypically diverse, SARS-CoV-2-infectible human cell lines representing different body organs and performed longitudinal survey of cellular proteins and pathways broadly affected by the virus. This revealed universal inhibition of interferon signaling across cell types following SARS-CoV-2 infection. We performed systematic analyses of the JAK-STAT pathway in a broad range of cellular systems, including immortalized cells and primary-like cardiomyocytes, and found that SARS-CoV-2 targeted the proximal pathway components, inclu

SUBMITTER: Chen DY 

PROVIDER: S-EPMC8428404 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature