Confirmation of a Causal Taar1 Allelic Variant in Addiction-Relevant Methamphetamine Behaviors.

ABSTRACT: Sensitivity to rewarding and reinforcing drug effects has a critical role in initial use, but the role of initial aversive drug effects has received less attention. Methamphetamine effects on dopamine re-uptake and efflux are associated with its addiction potential. However, methamphetamine also serves as a substrate for the trace amine-associated receptor 1 (TAAR1). Growing evidence in animal models indicates that increasing TAAR1 function reduces drug self-administration and intake. We previously determined that a non-synonymous single nucleotide polymorphism (SNP) in Taar1 predicts a conformational change in the receptor that has functional consequences. A Taar1 ^m1J mutant allele existing in DBA/2J mice expresses a non-functional receptor. In compa

SUBMITTER: Phillips TJ 

PROVIDER: S-EPMC8428522 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature