Pineoblastoma in children less than six years of age: The Head Start I, II, and III experience.

ABSTRACT:

Background

We report the outcomes of patients with pineoblastoma and trilateral retinoblastoma syndrome enrolled on the Head Start (HS) I-III trials.

Methods

Twenty-three children were enrolled prospectively between 1991 and 2009. Treatment included maximal surgical resection followed by five cycles of intensive chemotherapy and consolidation with marrow-ablative chemotherapy and autologous hematopoietic cell rescue (HDCx/AuHCR). Irradiation following consolidation was reserved for children over six years of age or those with residual tumor at the end of induction.

Results

Median age was 3.12 years (range, 0.44-5.72). Three patients withdrew from the study treatment and two patients experienced chemotherapy-related death. Eight patients experienced progressive disease

SUBMITTER: Abdelbaki MS 

PROVIDER: S-EPMC8428681 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature