Leucine-rich alpha-2-glycoprotein 1 and angiotensinogen as diagnostic biomarkers for Kawasaki disease.

ABSTRACT:

Objective

Kawasaki disease (KD) is a systemic vasculitis in childhood that can lead to coronary artery lesions (CALs). Although early diagnosis and treatment is important for preventing KD patients from development of CALs, diagnosis depends on the clinical features of KD. We studied the usefulness of leucine-rich alpha-2-glycoprotein 1 (LRG1) and angiotensinogen (AGT), previously reported as KD-related proteins, for KD diagnosis and estimation of intravenous immunoglobulin (IVIG) efficacy.

Methods

We undertook a prospective cohort study with patients having two or more KD symptoms in multiple centers in Japan, between July 2017 and February 2019.

Results

Two hundred forty-two patients were included. In multivariable analysis, one unit increase in LRG1 was associated

SUBMITTER: Yanagimachi M 

PROVIDER: S-EPMC8428710 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature